I am a long time lurker and user of TwonkyMedia, primarily with Netgear MP101 wireless client, just thought you might be interested in this.

I have developed an experimental http://www.last.fm scrobbler to submit listened to tracks from TwonkyMedia (V4.1 onwards) utilising the in-built RSS feature. The TwonkyScobbler monitors the ‘last played’ feed and when the last entry changes submits the appropriate information.
It runs on windows and requires .NET 2.0 framework – I have only tested it on my Windows XP machine and only with mp3 files at present.
More information and a link to the zip file at
http://www.insanityworks.co.uk/twonkysc ... /index.htm
Please note this is experimental, please read the documentation on how to set it up, it is important that the feed is set up correctly and this has to be done manually at the moment!
But you are welcome to download it and give it a try.
Andrew