I've searched the files to see where this is configured but am unable to locate it (using readynas with Twonky)
Can anybody give a pointer to where this might be located?

I tried waiting for 5.1.3-RC2 but the new release next week statement is 3 weeks old now and official-support has not responded to a query by me.

Slightly p*** as I have bought the upgrade 2 months ago and none of the versions work well. And now it looks like we have to buy an upgrade again to 6.x by end march

Thanks to Larry, it's a Twonky feature RTFM (which I had done many times but obviously not well enough....)
The manual states:
Option name: disablelocalssdp
Values: 0 / 1
Set to 1 to disable SSDP advertizing on localhost (127.0.0.1) network interface.
Default value is 0.
So either by issuing http://twonky_IP:9000/rpc/set_option?disablelocalssdp=1 and restart server or better set the option disablelocalssdp=1 in the twonky.ini twonky no longer advertises itself on the loopback address